Time: 9.11.2017 at 15:00-16:00
Venue: University of Eastern Finland (UEF), Kuopio campus, Medistudia building, Auditorium MS302 (address: Yliopistonranta 1A)
The Faculty of Health Sciences will organize a guest speaker seminar. The seminar is free of charge and open to all interested. No registration needed. The seminar is hosted by Professor Rashid Giniatullin and it will be held in English. Welcome!
Neurotoxins and Cys-loop receptors: old and new, bad and good
Lecture by Professor Victor Tsetlin
Prof. Tsetlin is a Head of the Dept. Molecular Basis of Neurosignaling at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Moscow). He also worked at the Uppsala University, Imperial College (London), Institute of Protein Research (Osaka) and Free University of Berlin awarded by the Alexander Humbodt Prize. He published >200 papers, including those in PNAS, Neuron, Nature Str. Mol. Biol.
Professor Tsetlin is the leading world expert in the field of neurotoxic peptides and proteins targeting nicotinic and other Cys-loop receptors.
In his lecture ‘Neurotoxins and Cys-loop receptors: old and new, bad and good’ he will present the proteomics of different animal venoms and discovery of peptides and proteins of novel structural types. These ligands are specific tools to study the Cys-loop receptors (receptors for acetylcholine, serotonin, glycine and GABA). Remarkably, a so-called three-finger spatial structure typical for the snake venom neurotoxins was recently found in human Ly6 proteins. The neurotoxins could be “good” as some of them became drugs as exemplified by recently completed preclinical study of one of the snake venom peptides in the lab of Prof. Tsetlin.
Key papersCelie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB. Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant. Nat Struct Mol Biol. 2005 Jul;12(7):582-8 Tsetlin VI.Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators. Trends Pharmacol Sci. 2015 Feb;36(2):109-23.
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