1 April Register-based studies on statin effectiveness and its possibilities and pitfalls. Seminar series 'Registers as a data source for effectiveness and patient safety research', Kuopio

The seminar series 'Registers as a data source for effectiveness and patient safety research' continues on April 1st at 2.15pm-3.45pm at S10 (Please note the change in date+place!) with Dr Maarit Korhonen's talk ‘Register-based studies on statin effectiveness and its possibilities and pitfalls‘.

Abstract of the talk: Use of computerized data generated through healthcare systems has increased tremendously in epidemiologic research, especially when studying the benefits and harms of drugs after the marketing approval. While the healthcare utilization databases have the potential to enable very large studies of research questions that are infeasible or impossible to be addressed with more traditional means, this potential must be balanced with the weaknesses of the register data. Using published studies on statins as examples, the presentation will discuss various design features of drug effectiveness studies, their potential impact on the validity of study results and ways to improve the validity.  Common sources of bias such as immortal time bias, healthy user/adherer effect, and confounding by indication, as well as means to mitigate these biases such as incident user design, use of negative exposures and controls, and application of propensity score methods, will be covered.

Maarit Jaana Korhonen is a pharmacist and epidemiologist with over 10 years of research experience in various fields of epidemiology. Dr. Korhonen currently serves as a senior adviser in the STATEAM project, the Department of Pharmacology, Drug Development and Therapeutics, as well as an adjunct professor at the Department of Public Health, University of Turku. Her research interests include, but are not limited to, the development and application of epidemiological methods for observational studies of pharmacotherapies using register data, focusing in particular on understanding the patient adherence and detecting and controlling confounding bias in drug effectiveness studies.

All interested participants are warmly welcome and no pre-registration is required. The program of the seminar series is available at http://www.uef.fi/fi/receps/seminaarisarja.

Additional Information: Anna-Maija Tolppanen, Reseach Centre for Comparative Effectiveness and Patient Safety, anna-maija.tolppanen(at)uef.fi

Publishing year: 2014

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