25.2. Models for elastography-based monitoring of focused ultrasound surgery and diagnostics

Public examination of a doctoral dissertation in the field of medical physics

 Doctoral candidate: M.Sc. Janne Heikkilä 

Date and venue: 25.2.2011 at 12 noon, Mediteknia auditorium, Kuopio campus  

ABSTRACT 

New focused ultrasound based diagnostic and therapeutic techniques and applications have been developed during the past decades. New therapy applications have been developed to manipulate soft tissue completely noninvasively. For example, living tissue can be destroyed by inducing thermal coagulation or permeability of tissue can temporarily be increased for large molecules. Diagnostic techniques have been developed to acquire not only an image of tissue structure, but also more quantitative information about the mechanical properties of soft tissue. 

In this thesis, a simulation model for ultrasound radiation force elastography has been developed and used to simulate ultrasound elastography based monitoring of focused ultrasound surgery (FUS) and ultrasound radiation force based vessel wall diagnostics.   

Simulation results show that ultrasound elastography, especially harmonic motion imaging, could be a feasible technique for FUS monitoring. Currently, all clinical FUS applications are based on magnetic resonance imaging monitoring, which imposes special requirements for the sonication apparatus, and thus other possible monitoring techniques have been investigated. Simulations of ultrasound radiation force based vessel wall diagnostics demonstrate that such techniques can detect stiffness changes in the vessel wall.   

Reliable simulation models are very important in development of new biomedical ultrasound methods because they can replace many complex, time consuming, and expensive experiments. The simulation model developed in this thesis can be used for optimization and parameter studies in further development of elastography and ultrasound techniques. 

The doctoral dissertation of Janne Heikkilä entitled Models for elastography-based monitoring of focused ultrasound surgery and diagnostics will be examined at the Faculty of Science and Forestry. The opponent in the public examination is J. Brian Fowlkes, Basic Radiological Sciences Division, Department of Radiology, University of Michigan Health and the custos is Professor Kullervo Hynynen, University of Toronto, Department of Medical Biophysics, Sunnybrook Health Sciences Centre and University of Eastern Finland.

Photo available for download at http://www.uef.fi/vaitoskuvat

Contact: Janne Heikkilä, tel +358 50 546 2702, Janne.Heikkila@uef.fi 

Publishing year: 2011

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